Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

303open jobs
$108k–$175ktypical salary
147companies hiring
2added this week
93%remote

Open Python roles

66 jobs

Blockchain Developer

Swift · Remote
Direct applyblockchaindistributed ledger technologysmart contractsEthereum
$101k–$188k 5 months ago View →

Derivatives Engineer

Galaxy Digital · Remote
Direct applyPythonGoJavaKafka
$175k–$220k 5 months ago View →

Quantitative Analyst, Derivatives & Financing

Anchorage · Remote
Direct applyquantitative analysisfinancial modelingPythonrisk management
$98k–$162k 5 months ago View →

Product Engineer

Sherlock · Remote
Direct applyPythonNext.jsTypeScriptLLMs
$80k–$160k 5 months ago View →

Data Scientist

Deel · Remote
Direct applyPythonSQLdata sciencemachine learning
$81k–$138k 5 months ago View →

Payments Risk Analyst II

Coinbase · Remote
Direct applydata analysisSQLMySQLfraud detection
$68k–$112k 5 months ago View →

Junior Derivatives Trader

Anchorage · Remote
Direct applyderivativestradingrisk managementquantitative analysis
$120k–$200k 5 months ago View →

Payments Risk Analyst II

Coinbase · Remote
Direct applySQLMySQLdata analysisdata visualization
$102k–$110k 5 months ago View →

Analyst (FP&A)

Eqvilent · Remote
Direct applyPythonMS Officeworkflow automation platforms
$63k–$109k 5 months ago View →

Analytics Engineer

Coinbase · Remote
Direct applySQLPythondata modelingdbt
$82k–$138k 5 months ago View →

Senior Site Reliability Engineer

Bloxstaking · Remote
Direct applyKubernetesArgoCDTerraformCrossplane
$82k–$112k 5 months ago View →

Senior Blockchain Engineer (Rust) & Senior Data Engineer

Trust Wallet · Remote
Direct applyRustGoC++AWS
$90k–$140k 5 months ago View →

Senior Engineer

Aetherum.ai · Remote
Direct applyTypeScriptNestJSReactPython
$125k–$225k 6 months ago View →

Senior Software Engineer, Backend

Coinbase · Remote
Direct applyPythonJavaJavaScriptGo
$128k–$212k 6 months ago View →

Fixed Income Operations Analyst

Dvtrading · Remote
Direct applyExcelVBASQLPython
$66k–$78k 6 months ago View →

Engineering Lead - Crypto and DeFi

Kast · Remote
Direct applyGoPythonNode.jsSolana
$175k–$250k 6 months ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.