Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

288open jobs
$112k–$180ktypical salary
148companies hiring
2added this week
100%remote

Open Python roles

288 jobs

Quant Researcher

Crypto.com · Remote
PythonSQLnoSQLdata structures
$100k–$230k 2 months ago View →

Risk Manager

Crypto.com · Remote
PythonSQL
$100k–$200k 2 months ago View →

Senior Pre-Sales Engineer

Incode · Remote
AndroidSwiftPythonKotlin
$112k–$188k 2 months ago View →

Head of Data Science - Generative AI

N26 · Remote
Generative AIMachine LearningPythonMLOps
$55k–$88k 2 months ago View →

Senior Data Scientist, Rides Safety

Bolt · Remote
machine learningPythonSQL
$36k–$59k 2 months ago View →

Senior Security Engineer

NEAR Foundation · Remote
IAMendpointcloudPython
$130k–$180k 2 months ago View →

Senior Frontend Engineer

HumanSignal · Remote
PythonDjangoJavaScriptTypeScript
$115k–$196k 2 months ago View →

Data Analytics AI Engineer

Fireblocks · Remote
AI/MLSQLPythonLLMs
$156k–$204k 2 months ago View →

Machine Learning Engineer

Checkr · Remote
PythonML systemsLLM APIsCI/CD
$100k–$150k 3 months ago View →

Senior Principal Applied Scientist - ZMS (all genders)

Growth Content Creator · Remote
Machine LearningOptimizationControl TheoryReinforcement Learning
$140k–$210k 3 months ago View →

Security Response Engineer, Incident Response

Chainlink Labs · Remote
incident responsemacOSPythonGo
$154k–$360k 3 months ago View →

AI/ML Engineer (all genders)

sunday · Remote
PythonML/DL librariesscikit-learnTensorFlow
$65k–$95k 3 months ago View →

Product Analyst

Aviasales · Remote
SQLPythondata analyticsdata architecture
$92k–$150k 3 months ago View →

Quantitative Trader (Associate/VP) - Onchain Trading

Galaxy Digital · Remote
PythonDeFialgorithmic tradingdata analysis
$150k–$200k 3 months ago View →

VP, Protocol Engineer (Validators)

Galaxydigitalservices · Remote
PythonLinux SystemsGCPAWS
$68k–$112k 3 months ago View →

Senior LLM Systems Engineer

Risk Labs · Remote
PythonTypeScriptPostgresGCP
$100k–$200k 3 months ago View →

Senior Blockchain/Web3 Engineer

Rather Labs · Remote
Soliditysmart contractsEVMJavaScript
$180k–$180k 3 months ago View →

Senior Backend Engineer

HumanSignal · Remote
PythonDjangoPostgresRedis
$115k–$196k 3 months ago View →

Senior Analytics Engineer

Alpaca · Remote
SQLDBTPythonPostgres
$117k–$127k 3 months ago View →

Senior Business System Analyst

Symfa · Remote
Microsoft SQL Serverdata reconciliationdata qualityPython
$127k–$196k 3 months ago View →

Vice President Security Engineering (Data Centers)

Galaxydigitalservices · Remote
Incident ResponsePythonXDRCI/CD
$120k–$200k 3 months ago View →

Site Reliability Engineer

Alpaca · Remote
Incident ResponseSRELinuxPython
$98k–$162k 3 months ago View →

Senior Software Engineer - Core Trading

Alpaca · Remote
C++GoZigRust
$98k–$162k 3 months ago View →

Senior Security Engineer

Nearfoundation · Remote
information securityIT engineeringSOC II Type 2ISO 27001
$120k–$150k 3 months ago View →

Senior C++ Developer

Movavi · Remote
C++17C++20QtObjective-C
$115k–$196k 3 months ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.