Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

254open jobs
$111k–$180ktypical salary
129companies hiring
10added this week
100%remote

Open Python roles

254 jobs

Senior Principal Applied Scientist - ZMS (all genders)

Growth Content Creator · Remote
Machine LearningOptimizationControl TheoryReinforcement Learning
$140k–$210k 1 month ago View →

Security Response Engineer, Incident Response

Chainlink Labs · Remote
incident responsemacOSPythonGo
$154k–$360k 1 month ago View →

AI/ML Engineer (all genders)

sunday · Remote
PythonML/DL librariesscikit-learnTensorFlow
$65k–$95k 1 month ago View →

Product Analyst

Aviasales · Remote
SQLPythondata analyticsdata architecture
$92k–$150k 1 month ago View →

Quantitative Trader (Associate/VP) - Onchain Trading

Galaxy Digital · Remote
PythonDeFialgorithmic tradingdata analysis
$150k–$200k 1 month ago View →

VP, Protocol Engineer (Validators)

Galaxydigitalservices · Remote
PythonLinux SystemsGCPAWS
$68k–$112k 1 month ago View →

Senior LLM Systems Engineer

Risk Labs · Remote
PythonTypeScriptPostgresGCP
$100k–$200k 1 month ago View →

Senior Blockchain/Web3 Engineer

Rather Labs · Remote
Soliditysmart contractsEVMJavaScript
$180k–$180k 1 month ago View →

Senior Backend Engineer

HumanSignal · Remote
PythonDjangoPostgresRedis
$115k–$196k 1 month ago View →

Senior Analytics Engineer

Alpaca · Remote
SQLDBTPythonPostgres
$117k–$127k 1 month ago View →

Senior Business System Analyst

Symfa · Remote
Microsoft SQL Serverdata reconciliationdata qualityPython
$127k–$196k 1 month ago View →

Vice President Security Engineering (Data Centers)

Galaxydigitalservices · Remote
Incident ResponsePythonXDRCI/CD
$120k–$200k 1 month ago View →

Site Reliability Engineer

Alpaca · Remote
Incident ResponseSRELinuxPython
$98k–$162k 1 month ago View →

Senior Software Engineer - Core Trading

Alpaca · Remote
C++GoZigRust
$98k–$162k 1 month ago View →

Senior Security Engineer

Nearfoundation · Remote
information securityIT engineeringSOC II Type 2ISO 27001
$120k–$150k 1 month ago View →

Senior C++ Developer

Movavi · Remote
C++17C++20QtObjective-C
$115k–$196k 1 month ago View →

Senior Systems Reliability Engineer - IEX

IEX · Remote
Linuxpythonbashgit
$150k–$225k 1 month ago View →

Counterparty Credit Risk Analyst

N26 · Remote
SQLPython
$34k–$56k 1 month ago View →

Senior Backend Engineer

Zerion · Remote
DockerKubernetesPostgresMongoDB
$115k–$196k 1 month ago View →

Junior Blockchain Accountant

General Tensor · Remote
accountingfinancecryptoGAAP
$50k–$60k 1 month ago View →

VP, Quantitative Developer - Risk Engineering

Galaxy Digital · Remote
PythonAISQLBeacon Platform
$225k–$280k 1 month ago View →

Privacy Automation Engineer

Binance · Remote
PythonAILLMREST APIs
$68k–$112k 1 month ago View →

Middle DevOps specialist

Asodesk · Remote
DockerKubernetesPostgresNginx
$38k–$38k 1 month ago View →

Vice President Site Reliability Engineering (Data Centers)

Galaxydigitalservices · Remote
Observability ToolsPackerLinuxPython
$120k–$200k 1 month ago View →

Blockchain Security AI Application Support Engineer

Crypto · Remote
AIBlockchainRustPython
$75k–$125k 1 month ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.