Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

288open jobs
$112k–$180ktypical salary
148companies hiring
2added this week
100%remote

Open Python roles

288 jobs

Technical Support Engineer

Zscaler · Remote
firewallspacket filteringHTTP/HTTPSIPv4
$70k–$155k 4 months ago View →

Sr. Staff Technical Program Manager - Hosted Infrastructure Operations

Zscaler · Remote
networkingcloud operationsinfrastructuredata center technologies
$140k–$200k 4 months ago View →

Staff Site Reliability Engineer-Federal, Security Clearance

Zscaler · Remote
AWSLinuxAnsibleTerraform
$119k–$170k 4 months ago View →

DeFi Risk Analyst

Morpho · Remote
SQLPythonR
$95k–$170k 4 months ago View →

Data Scientist - Credit Risk

Divine · Remote
PythonSQLGrafanaPrometheus
$135k–$237k 4 months ago View →

Blockchain Developer

Harris Allied · Remote
SolidityJavaTypescriptPython
$175k–$195k 4 months ago View →

Senior Post Listing Account Manager

Binance · Remote
Google suiteSQLPythonDune analytics
$76k–$220k 4 months ago View →

Machine Learning Engineer Intern

Tether Operations Limited · Remote
PythonPyTorchdeep learninggenerative modeling
$60k–$90k 4 months ago View →

Lead Technical Product Manager

Zinnia · Remote
Cloud NativeSaaSSQLPython
$170k–$190k 5 months ago View →

DevSecOps Engineer

Alpaca · Remote
KubernetesTerraformPythonGo
$75k–$125k 5 months ago View →

Developer Relations Engineer (CIS-based)

TON Foundation · Remote
RustJavaPythonTypeScript
$120k–$220k 5 months ago View →

Internal Audit IT Manager

Coinbase · Remote
AWSGCPPythonSQL
$82k–$196k 5 months ago View →

Data Analyst

Dominion Capital · Remote
SQLPythonTableauPower BI
$90k–$102k 5 months ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.