Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

288open jobs
$112k–$180ktypical salary
148companies hiring
2added this week
100%remote

Open Python roles

288 jobs

Agentic AI Engineer

Eigen Labs · Remote
PythonGoTypeScriptRust
$187k–$253k 4 months ago View →

Senior FullStack Developer

Palta · Remote
ReactGoNodeJSJavaScript
$115k–$196k 4 months ago View →

AI Agent Platform Engineer

Binance · Remote
TypeScriptPythonOpenClawLangGraph
$180k–$219k 4 months ago View →

Research Analyst

Tether Operations Limited · Remote
SQLRPythonGitHub
$140k–$230k 4 months ago View →

DeFi Yield Strategist

Cannon Ventures · Remote
PythonSQLDuneNansen
$95k–$145k 4 months ago View →

Senior Software Engineer

Toku · Remote
TypeScriptPythonReactNode.js
$165k–$220k 4 months ago View →

Senior Solutions Engineer (API, Python, Node.JS)

Binance · Remote
APIPythonNode.jsREST APIs
$112k–$188k 4 months ago View →

Binance Accelerator Program - Data Scientist (LLM & Trading)

Binance · Remote
GolangPythonAIData Analysis
$112k–$188k 4 months ago View →

Member of Global Risk Management, Quantitative Financial Risk

Anchorage Digital · Remote
Python
$82k–$138k 4 months ago View →

Member of Compliance, Financial Crimes Compliance Data Analytics

Anchorage Digital · Remote
SQLLookerExcelGoogle Sheets
$120k–$200k 4 months ago View →

AI Engineer

Chaos Labs · Remote
PythonAPI designLangGraphMCP servers
$150k–$213k 4 months ago View →

Data Scientist/Product Analytics

RiskPod · Remote
PythonSQLstatisticsexperimentation design
$150k–$180k 4 months ago View →

Binance Accelerator Program - Data Scientist (LLM Trading)

Binance · Remote
GolangPython
$140k–$205k 4 months ago View →

Senior Solutions Engineer (API, Python, Node.JS)

Binance · Remote
APIPythonNode.jsREST APIs
$176k–$300k 4 months ago View →

Security Engineer - Jito Labs

Jito Labs · Remote
RustGoPythonC++
$175k–$195k 4 months ago View →

Financial Analyst

Divergence VC · Remote
ExcelPythonRTradingView
$100k–$124k 4 months ago View →

Senior Engineer

Aetherum.ai · Remote
TypeScriptNestJSReactPython
$125k–$225k 4 months ago View →

Intern - AI and Automation

Impossible Cloud · Remote
AI toolsautomation platformsn8nMake
$40k–$72k 4 months ago View →

Member of Global Risk Management, Quantitative Financial Risk

Anchorage Digital · Remote
Python
$30k–$186k 4 months ago View →

Senior Software Engineer, Backend

Coinbase · Remote
PythonJavaJavaScriptGo
$128k–$212k 4 months ago View →

Software Engineer: Core (Remote)

Constructor · Remote
RustC++PythonAWS
$81k–$138k 4 months ago View →

Engineering Team Lead

Adapty · Remote
PythonPostgreSQLClickHouseKafka
$150k–$242k 4 months ago View →

CI/CD Engineer

Betby · Remote
GitLab CIPythonDockerKubernetes
$81k–$138k 4 months ago View →

Fixed Income Operations Analyst

Dvtrading · Remote
ExcelVBASQLPython
$66k–$78k 4 months ago View →

Solutions Architect

Lorikeet · Remote
TypeScriptReactRemixPrismaORM
$102k–$225k 4 months ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.