Python Jobs in Crypto & Web3

Python shows up across web3 in data analytics, on-chain research, trading and MEV bots, and tooling. Libraries like web3.py let engineers query nodes and decode events, while pandas and the broader data stack power dashboards, risk models, and protocol analytics that inform real decisions.

Employers hiring Python developers often want someone who can pull and clean on-chain data, build backtesting or monitoring pipelines, and prototype quickly. Roles range from quantitative research at trading desks to backend services and data engineering at protocols, where reliability and clear reproducible analysis matter as much as raw modeling skill.

255open jobs
$110k–$180ktypical salary
130companies hiring
9added this week
100%remote

Open Python roles

255 jobs

Senior DevOps Engineer

Risk Labs · Remote
TerraformBashPythonTypescript
$100k–$200k 2 months ago View →

Senior Blockchain Engineer (Rust) & Senior Data Engineer

Trust Wallet · Remote
RustGoC++AWS
$90k–$140k 2 months ago View →

Python Engineer

Checkr · Remote
PythonJavaScriptRESTful APIs
$100k–$150k 2 months ago View →

Senior Blockchain Engineer

JSoft Labs · Remote
blockchainsmart contractsSolidityRust
$100k–$140k 2 months ago View →

Senior/Staff Machine Learning Engineer

River · Remote
XGBoostPyTorchPythonMLflow
$150k–$250k 2 months ago View →

Principal Security Engineer, Research & Engineering

Trail of Bits · Remote
RustC++PythonGo
$200k–$250k 2 months ago View →

Software Engineer - Affirmative for People with Disabilities

Neon · Remote
Golang.NETC#Python
$81k–$138k 2 months ago View →

Technical Operations Analyst

Coins.ph · Remote
JiraConfluenceJavaPython
$120k–$220k 2 months ago View →

Senior SRE (blockchain networks)

P2P.org · Remote
KubernetesTerraformLinuxGCP
$138k–$220k 2 months ago View →

AI Native Platform Architect

Okx · Remote
JavaPythonLangChainLangGraph
$180k–$219k 2 months ago View →

Tokenization and Investment Operations Specialist

Centrifuge · Remote
ERC-4626ERC-7540MPC walletsPython
$52k–$88k 2 months ago View →

Data Governance and Management Lead

Anchorage · Remote
SQLPythonLookerPower BI
$135k–$225k 2 months ago View →

Capital and Risk Analytics Lead

Anchorage Digital · Remote
PythonR
$120k–$200k 2 months ago View →

Backend Engineer: Ranking

Constructor · Remote
PythonCloudFormationTerraformAWS
$81k–$138k 2 months ago View →

Senior Risk Engineer

Luxoft · Remote
PythonAWSGCPAzure
$115k–$196k 2 months ago View →

Data Governance and Management Lead

Anchorage Digital · Remote
SQLPythonLookerPower BI
$117k–$218k 2 months ago View →

Senior Backend Engineer (Python/Java)

BTSE · Remote
PythonJavaFastAPIHTML
$135k–$225k 2 months ago View →

Agentic AI Engineer

Eigen Labs · Remote
PythonGoTypeScriptRust
$187k–$253k 2 months ago View →

Senior FullStack Developer

Palta · Remote
ReactGoNodeJSJavaScript
$115k–$196k 2 months ago View →

AI Agent Platform Engineer

Binance · Remote
TypeScriptPythonOpenClawLangGraph
$180k–$219k 2 months ago View →

Research Analyst

Tether Operations Limited · Remote
SQLRPythonGitHub
$140k–$230k 2 months ago View →

DeFi Yield Strategist

Cannon Ventures · Remote
PythonSQLDuneNansen
$95k–$145k 2 months ago View →

Senior Software Engineer

Toku · Remote
TypeScriptPythonReactNode.js
$165k–$220k 2 months ago View →

Senior Solutions Engineer (API, Python, Node.JS)

Binance · Remote
APIPythonNode.jsREST APIs
$112k–$188k 2 months ago View →

Binance Accelerator Program - Data Scientist (LLM & Trading)

Binance · Remote
GolangPythonAIData Analysis
$112k–$188k 2 months ago View →

Frequently asked questions

Is Python used for smart contract development?
Rarely for production contracts, though Vyper borrows Python-like syntax. Python's strength in web3 is data, analytics, automation, and bots rather than on-chain logic.
What library do I use to read blockchain data in Python?
Web3.py is the standard for interacting with Ethereum nodes, decoding events, and sending transactions. Many analytics roles also rely on indexed datasets and SQL.
Can Python skills land a quant or MEV role?
Yes. Trading desks and MEV teams use Python heavily for research and prototyping, often alongside Rust or C++ for latency-critical execution.